Alzheimer's Disease in Under-represented Populations

 
   Lead Investigator:    Li Liu
   Institution      :    Arizona State University
   E-Mail           :    liliu@asu.edu
   Proposal ID      :    829


   Publications:


1  Liu L
   Effect of APOE Genotype on Alzheimer's Disease Diminishes in Octogenarians
   2018   Abstract  2018 Arizona Alzheimer's Consortium Retreat , 

   PRESENTED



2  Liu L, Caselli R
   Age stratification corrects bias in estimated hazards of APOE Genotype in Alzheimer's disease
   Journal Article  Alzheimers Dement (N.Y),4:602-608,2018,PMC6226550

   PUBLISHED





   Proposal Description:
   Traditional statistical methods have low power in discovering disease             biomarkers in under-represented populations due to the small sample sizes. In     this study, we propose a machine-learning approach that borrows knowledge from    well-represented populations to assist biomarker discovery in under-represented   populations. These biomarkers may include clinical parameters,                    neuropsychological test results, demographic characteristics, imaging features    and/or genomic data. Using these markers, we will develop a prognostic model of   progression of Alzheimer???s disease for the Caucasian cohort and for the         Hispanic cohort.